Red Cell Genotyping - Areas of Expertise

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Red Cell Genotyping for Immune Mediated Destruction
For more than 50 years, BloodCenter has helped blood banks and clinicians solve their most difficult transfusion problems. We understand your challenges and have designed our Red Blood Cell genotyping services to help you meet those challenges every day.

Red Blood Cell Genotyping Overview 6-1-13 RCG Overview BloodCenter of Wisconsin can deliver results faster and more cost effectively than other labs. More importantly, we also provide you with confidence in your results and patient care.

BloodCenter’s RBC genotyping services will help you:

Improve transfusion patient care
Reduce red cell alloimmunization
Enhance red cell utilization
Potentially reduce donor base screening costs

Red Cell Genotyping Approach

Improving patient care in prenatal and transfusion cases

6-1-13 RCG Approach

Patient Genotyping Panels

BloodCenter of Wisconsin’s patient Red Blood Cell (RBC) genotyping panels can provide you the accuracy and confidence to ensure the highest quality of transfusion patient care. Our genotyping service allows you to characterize the alleles associated with clinically significant blood group antigens before or during treatment. These panels are especially beneficial for patients presenting with warm autoantibodies, positive DATs, and those who have been recently transfused.

Our panels fulfill all the requirements needed in today’s transfusion service:

Clinically significant antigens
Rapid turnaround time of less than 72 hours
Market-sensitive pricing

Prenatal Diagnostics

BloodCenter of Wisconsin is a pioneer in prenatal red blood cell genotyping. We began offering this testing in 1995, and have over 16 years of expertise in Hemolytic Disease of the Newborn. Our physicians are always available to consult on high-risk pregnancy management, including intrauterine transfusions.

BloodCenter prenatal RBC genotyping services include:

Single antigen system testing
Case-based evaluations of mother, father and fetus
Phenotyping to rule in/out variant alleles
Antigen-negative and CMV-negative red cell products for intrauterine transfusions

Donor Screening

BloodCenter of Wisconsin’s donor red cell genotyping can help you build a well characterized donor pool so you can meet the transfusion needs of future patients. Our service covers common and rare antigens, including those found in patients with sickle cell disease and thalassemia. Compared to serological antigen typing, BloodCenter’s high-throughput approach provides cost savings and exceptional patient care.

BloodCenter’s donor screening service will help you:

Potentially reduce donor RBC antigen screening costs
Quickly identify antigen negative units
Provide excellent patient care

Red Blood Cell Genotyping Tests
Transfusion Patient Testing

Common Panel:
C, c, E, e, M, N, S, s, K, k, Fya, Fyb, Jka, Jkb, Jsa, Jsb, Doa, Dob,
Lua, Lub, Kpa, Kpb, U, Uvar

Rh Variant Panel:
C, c, E, e, (including ces), hrS, hrB, altered C (r’S), V, VS, Crawford (RH43)

RhD Discrepancy Analysis (Weak D Analysis)

Partial D Analysis

Prenatal Diagnostics

BloodCenter of Wisconsin offers prenatal testing for the following single antigens:

Duffy (Fya/Fyb)
Kell (K1/K2)
Kidd (Jka/Jkb)
M
Rh C/c
Rh D
Rh E/e
S and s

RhD Zygosity

Donor Screening

BloodCenter also offers donor screening genotyping. Please contact us for more information.

Red Blood Cell Genotyping References

Denomme GA. Molecular basis of blood group expression. Transfusion and Apheresis Science. 2011; 44:53-63

Hopp K, Weber K, Bellissimo B, Johnson ST, Pietz B. High-throughput red blood cell antigen genotyping using a nanofluidic real-time polymerase chain reaction platform. Transfusion. 2010; 50(1):40-46

Denomme GA, Flegel WA. Applying molecular immunohematology discoveries to standards of practice in blood banks: now is the time. Transfusion. 2008; 48:2461-2475

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