Patients facing transplant surgery need to be carefully matched with compatible donors. BloodCenter’s Diagnostic Laboratories specializes in identifying the best donors possible for patients who need a transplant. After transplant, tests to monitor immune status help the transplant surgeon identify possible instances of organ rejection to prevent loss of the transplanted organ.
BloodCenter of Wisconsin’s transplant immunology experts have an international reputation for diagnostic services, scientific excellence, and innovative approaches.
BloodCenter’s state-of-the-art Histocompatibility laboratory is designed to support solid organ transplant programs by providing rapid turnaround time for HLA typing. Our lab performs HLA Class I and Class II typing to help identify the best available donor for a patient in need of a solid organ transplant. Our lab also provides testing to detect and identify antibodies to HLA Class I and HLA Class II antigens to help identify the best donor for a patient with pre-formed HLA antibodies and crossmatching to confirm donor and patient compatibility. Our laboratory technical specialists and directors form strong relationships with our clinical partners, becoming part of the patient care team.
Our combination of skilled technologists, meticulous antibody testing and HLA matching, and expert directors who offer personal clinical consultation to help to identify the best care for your patient make Diagnostic Laboratories a leader in Solid Organ Transplantation. Together, we work with you to help you find the best care—and the best match—for your patients.
HLA-A Low Resolution
HLA-B Low Resolution
HLA-C Low Resolution
HLA-DRB1 Low Resolution
HLA-DRB3,4,5 Low Resolution
HLA-DQB1/DQA1 Low Resolution
HLA-DPB1 Low Resolution
HLA Antibody Detection (Flow Cytometric)
HLA Antibody Identification Class I High Resolution
HLA Antibody Identification Class II High Resolution
Crossmatch (Flow Cytometric)
Crossmatch (Flow Cytometric) Titration
Zangwill, S.D., Ellis, T.M., Zlotocha, J., Jaquiss, R.D., Tweddell, J.S., Mussatto, K.A., and Berger, S. The virtual crossmatch-a screening tool for sensitized pediatric heart transplant recipients. Pediatr. Transplant, 10:38-41, 2006.
Zangwill, S., Ellis, T., Stendahl, G., Zahn, A., Berger, S., and Tweddell, J. Practical application of the virtual crossmatch. Pediatr. Transplant. 11:650-654, 2007.
Schiller, J.J, Gaba, S., Fisher, T., Hasse, T. and Ellis, T.M. A novel HLA allele derived from a likely DRB1/DRB3 gene conversion event: HLA-DRB3*01:15. Tissue Antigens, 78:405-407, 2011.
Ellis, T.M., Schiller, J.J., Roza, A.M., Cronin, D.C., Shames, B.D., and Johnson, C.P. Diagnostic accuracy of solid phase HLA antibody assays for predicting crossmatch strength. Human Immunol. 73:796-710, 2012.
Schiller, J.J, Murrin, S. L., Rose, B.A., and Ellis, T.M. Differential Requirements for Complement Activation by HLA Antibodies Measured by Solid Phase C1q versus Complement-Mediated Cytolysis Assays. Submitted for Publication.