Clinical Research
The Medical Sciences Institute (MSI) leads development of clinical and translational research at BloodCenter of Wisconsin. Our clinical investigators, along with scientific colleagues worldwide, find new discoveries, treatments, and cures that make significant contributions to patient care locally, nationally, and internationally.

Clinical Trials 
Basic research involves experiments and studies that occur in a laboratory setting. Clinical trials, on the other hand, rely on the participation of human volunteers in order to answer questions about treatments for various conditions and diseases. The BloodCenter of Wisconsin is conducting many clinical trials and is leading the way in the discovery, treatment and cure of patients. Areas of clinical research expertise include:
  • Bleeding and Clotting Disorders
  • Sickle Cell Disease
  • Transfusion Medicine
  • Blood Donor Studies
  • Contract Research 

Additional Clinical Trials information to be available in 2013.

Clinical research at BCW emphasizes:
  • Hematology
  • Transfusion medicine
  • Bleeding and clotting disorders
  • Sickle cell disease and anemias
  • Platelet, white cell and red cell disorders

Experienced 
BloodCenter’s clinical investigators have decades of experience in performing clinical research studies, and they continually make strides toward advancing care for cardiovascular disease, cancer, and bleeding and clotting disorders.

Collaborative
Through partnerships with Medical College of Wisconsin (MCW) and its Clinical Translational Science Institute (CTSI) and our partner local academic hospitals including Marshfield Clinic, MSI utilizes existing clinical resources to focus on established clinical programs in bleeding and clotting disorders, sickle cell disease and transfusion medicine.

Organized
As part of BloodCenter’s effort to advance clinical research, the MSI has established a Clinical Trials and Research Office (CTRO). The mission of the CTRO is to conduct clinical trials and research in a safe, compliant, expedient and cost-effective manner and enhance outstanding patient care.

Services of the CTRO include:
  • Pre and Post Grants Management
  • Trial design, activation, coordination, implementation & management
  • Data collection and management
  • Adverse event monitoring and reporting
  • Preparation of regulatory documents and submissions
  • Regulatory support and compliance monitoring
  • Development of trial budgets
  • Contract negotiations
  • Invoicing and revenue tracking
  • IRB Support
  • Sample collection, processing and management

Comprehensive
Research at BloodCenter of Wisconsin spans the clinical continuum from bench to bedside. The CTRO leverages its expertise in interventional, observational, epidemiological and even laboratory clinical studies. Other areas throughout BloodCenter of Wisconsin, including—Legal, Compliance, and IS—further support the CTRO and clinical researchers with services that range from contract approval and negotiation to protecting human research subjects, to IT, data management, and biorepository management. Together, this extended team collaborates to deliver a comprehensive approach to clinical research.

Clinical research progress is ongoing at BloodCenter of Wisconsin. Our clinical research team has made a difference in many lives by leading the way in the discovery, treatment and cure of patients.

Decreased post-surgical bleeding
Patients undergoing heart surgery often receive heparin to decrease the incidence of clotting. For some patients, however, heparin can induce excessive post-surgical bleeding. BloodCenter of Wisconsin researchers created a test for heparin-induced thrombocytopenia (HIT), so physicians can identify the source of this bleeding and discontinue heparin therapy.

Safer pregnancies
In certain instances, a pregnant woman’s immune system can react against the fetus and destroy its platelets. This condition is known as Neonatal Alloimmune Thrombocytopenic Purpura (NATP). BloodCenter of Wisconsin researchers were the first to identify the platelet markers most commonly implicated in NATP, and formulated a DNA detection test that has resulted in decreased fetal deaths.

More successful transplants
BloodCenter of Wisconsin researchers were the first to discover certain white cell markers, called HLA markers, which are important to match to maximize the success of a transplant. They then developed genetic typing that allows for more accurate matching of bone marrow donors with patients, decreasing the incidence of rejection.

Hope for newborns
Protein C-deficient newborns do not live long because their blood is unable to properly regulate the clotting process, causing them to have profound systemic clotting. BloodCenter of Wisconsin researchers defined the role of protein C in clot regulation, and created the first successful treatment for Protein C-deficient newborns.

Safer transfusions
Patients in need of frequent transfusions can develop reactions to the blood they receive. Through a technique involving the matching of certain markers on platelets, the incidence of reactions following transfusions has decreased.

Safer treatment for hemophilia patients
By early recognition of the risks of pooled product, BloodCenter of Wisconsin researchers helped to reduce the incidence of HIV in this population by providing an alternate product.

Extended Blood Supply
BloodCenter of Wisconsin researchers have determined methods for improving the quality and quantity of stored platelets. Those needing platelets include surgery patients, organ transplant recipients, and patients undergoing chemotherapy.

Better treatment for Sickle Cell patients
Researchers have participated in studies leading to improved treatments for sickle cell patients. Sickle cell disease impacts about 1 in 400 African-Americans.

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